China (Mainland)
2-Pyridinecarboxamide,4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl CAS NO.284461-73-0
- FOB Price: USD: 245.00-280.00 /Gram Get Latest Price
- Min.Order: 20 Gram
- Payment Terms: L/C,T/T
- Available Specifications:
meidical grade(20-60)Grammeidical grade(60-200)Grammeidical grade(200-500)Gram
- Product Details
Keywords
- 284461-73-0
- 2-Pyridinecarboxamide,4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl
- Sorafenib
Quick Details
- ProName: 2-Pyridinecarboxamide,4-[4-[[[[4-chlor...
- CasNo: 284461-73-0
- Molecular Formula: C21H16ClF3N4O3
- Appearance: white powder
- Application: food pharma
- DeliveryTime: within 7 working days after payment
- PackAge: as per client's requirement
- Port: Wuhan
- ProductionCapacity: 1000 Kilogram/Month
- Purity: ≥99%
- Storage: in cool, dry place
- Transportation: Cool dry place, away from the light;
- LimitNum: 20 Gram
- Moisture Content: ≤0.5
- Impurity: ≤1.0%
- Appearance: white powder
- Purity(HPLC): 99%min
- shelf life: two years
- water content: ≤0.5%
- loss on drying: ≤1.0%
- related impurity by hplc: ≤1.0%
Superiority
quality & price
1. factory price, reliable quality
2. years produce and exporting experience
3. strict quality control, free sample for test before order, keep sample after shipment for further issue
service
1. enough stock, fast shipment, professional team to deal with it
2. different packing can be customized, photos available before shipment
3. quick response for all inquiries or claims
wuhan xinru chemical has several stock-holding factories, based on strong r&d ability, advanced
production technology and experienced team; pluses international trade office in wuhan, we
can offer high and stable quality products with quick response and service.
please contact us freely for more details about products specification, packing method, price term,
lead time, payment term and any other information, we would try our best to satisfy you both on
quality and price as much as we can.
Details
Product name:sorafenib
synonyms:bay43-9006;n-[4-chloro-3-(trifluoromethyl)phenyl]-n'-[4-[2-(n-methylcarbamoyl)-4-pyridyloxy]phenyl]urea
specification: 98%
cas no.:284461-73-0
appearance: white crystalline powder
molecular weight: 464.82
molecular formula:c21h16clf3n4o3
|
items |
specifications |
results |
|
appearance |
off white powder to white powder |
off-white powder |
|
identification |
h-nmr, ms |
complies |
|
water content |
< 0.5% |
0.06% |
|
loss on drying |
<1.0% |
0.02% |
|
related impurity by hplc |
total impurity ≤1.0% single impurity≤0.3% |
0.05% 0.04% |
|
purity (hplc) |
≥99% |
99.95% |
function and application:
sorafenib is a raf kinase inhibitor which suppresses erk phosphorylation. studies indicate that sorafenib induces c-raf phosphorylation
at both ser-43 and ser-259. when combined with vitamin k1 phosphorylation is increased at these serine residues. sorafenib also induces the phosphorylation of pka. in addition, sorafenib induces c-met phosphorylation at tyr-1349, which consequently induces pi3k-akt phosphorylation. studies determined that sorafenib inhibits other kinases such as flk-1 (vegfr2), platelet-derived growth factor receptor (pdgfr), flt3, ret, and c-kit.